Michiel Vermeulen

Stichting Radboud Universitet (RU)

Biosketch 

Michiel Vermeulen studies gene expression regulation in health and disease using integrative omics approaches. He pioneered the application of quantitative interaction proteomics to identify and characterise proteins that specifically interact with epigenetic modifications (i.e. Cell 2007, Cell 2010, Cell 2013). He also published the first global interactomes for the mRNA modification m6A (NSMB 2017), ubiquitin linkages (Mol. Cell 2017) and ADP ribosylation (Mol. Cell 2021). Furthermore, he characterized a number of chromatin-associated proteins, which regulate embryonic and adult stem cell differentiation (i.e. NSMB 2016, Mol. Sys. Biol. 2019). In total, he authored > 150 scientific publications. Major grants include NWO-VIDI (2009) and VICI (2021), an ERC Starter (2012) and Consolidator (2017) grant and various other EU grants (i.e. Marie Curie ITN networks DevCom (FP7) and EpiSystem (H2020)). In 2019 he was elected as a member of Academia Europaea and in 2022 he was elected as member of EMBO

Selected publications

1. Reading ADP-ribosylation using chemical biology and interaction proteomics. Kliza KW, Liu Q, Roosenboom LWM, Jansen PWTC, Filippov DV, Vermeulen M. Mol Cell. 2021 Sep 15:S1097-2765(21)00717-6.
2. Off-the-shelf proximity biotinylation for interaction proteomics Santos-Barriopedro I, van Mierlo G, Vermeulen M. Nature Communications. 2021 Aug 18;12(1):5015.
3. N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis. Edupuganti RR, Geiger S, Lindeboom RGH, Shi H, Hsu PJ, Lu Z, Wang SY, Baltissen MPA, Jansen PWTC, Rossa M, Müller M, Stunnenberg HG, He C, Carell T, Vermeulen M. Nat Struct Mol Biol. 2017 Oct;24(10):870-878.
4. An interaction landscape of ubiquitin signaling Zhang X, Smits AH, van Tilburg GBA, Jansen PWTC, Makowski MM, Ovaa H, Vermeulen M. Molecular Cell 2017 Mar 2;65(5):941-955.e8.
5. Dynamic readers for 5-(hydroxy)methylcytosine and its oxidized derivatives. Spruijt CG, Gnerlich F*, Smits AH, Pfaffeneder T, Jansen PWTC, Bauer C, Münzel M, Wagner M, Müller M, Khan F, Eberl HC, Mensinga A, Brinkman AB, Lephikov K, Müller U, Walter J, Boelens R, Van Ingen H, Leonhardt H, Carell T, Vermeulen M. Cell. 2013. Feb 28;152(5):1146-59.

Description of partner organization

The Vermeulen lab is hosted by the Radboud Institute for Molecular Life Sciences (RIMLS) at the Radboud University Nijmegen, The Netherlands. The mission of the institute is to integrate fundamental questions and technologies in the life sciences with medical applications, with the ultimate aim being to have a significant impact on healthcare