Working on my PhD project is often like studying a vast and intricate picture. Each data set – RNA-seq, ChIP-seq, Micro-C – reveals a fragment, a brushstroke full of significance, but also incomplete on its own. The real challenge is taking a step back to see how these individual lines connect, forming a bigger picture of neural crest development and its disorder in Cornelia de Lange syndrome.

Data integration is more than a technical task: it is an act of interpretation that requires a constant shift between detail and perspective, between the molecular signature of a single enhancer and the orchestration of entire regulatory networks.

I am Lucio Di Filippo, a PhD student committed to understanding how changes in chromatin architecture and epigenetic regulation converge to shape developmental outcomes and how their misregulation leads to disease.

#PhDLife #Chromatin #Epigenetics